Opdivo was dosed every two weeks at three milligrams per 10 kilograms of weight. Yervoy is approved at 10 milligrams per 10 kilograms of weight. Opdivo and Keytruda, a rival from Dow component Merck ( MRK ), are both known as PD-1 inhibitors. Bristol's Yervoy is a CTLA-4 inhibitor. They all work to block specific interactions in the body that would prevent an immune response. "Although this likely will cannibalize sales of Yervoy in the setting, the expansion of the market should add approximately $1 billion to Bristol's net immuno-oncology sales despite assumed competition from Merck's Keytruda," Leerink analyst Seamus Fernandez said in a note to clients. The magnitude of the benefit of Opdivo over Yervoy wasn't released. Bristol hadn't expected to release such data until the second half of 2018, Fernandez said. acupuncture for rosaceaNow, Fernandez says, treatment with Opdivo following surgery in high-risk patients with melanoma could become the standard of care. Opdivo and Yervoy were tested with patients with late-stage melanoma in a trial dubbed Checkmate-238. IBD'S TAKE: The biotech rally sent several players to incredible highs.
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